Antifungal hydrogels

Antifungal hydrogels.

Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed. Amphogel kills fungi within 2 h of contact and can be reused for at least 53 days without losing ...

Injectable in situ cross-linking hydrogels for local antifungal therapy.

Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. We have developed an injectable local antifungal treatment for direct administration into existing or potential sites of fungal infection. Amphotericin B (AmB), a hydrophobic...

Sertaconazole-Loaded Cyclodextrin–Polysaccharide Hydrogels as Antifungal Devices

The aim of the present work was to develop novel hydrogels for delivering sertaconazole based on cyclodextrins and various biocompatible polysaccharides. Sertaconazole is an antifungal agent very effective for treatment of Candida albicans infections. However its poor aqueous solubility is still a challenging issue for developing suitable formulations. Complexation with cyclodextrins is a very ...

Templating hydrogels

Templating processes for creating polymerized hydrogels are reviewed. The use of contact photonic crystals and of non-contact colloidal crystalline arrays as templates are described and applications to chemical sensing and device fabrication are illustrated. Emulsion templating is illustrated in the formation of microporous membranes, and templating on reverse emulsions and double emulsions is ...

Antifungal application of non - antifungal drugs 1